A body mass index ≥25 kg/m2 is associated with a poor prognosis in patients with acute pancreatitis: a study of Japanese patients
Tsukasa Ikeura, Kota Kato, Makoto Takaoka, Masaaki Shimatani, Masanobu Kishimoto, Kenichiro Nishi, Shuji Kariya and Kazuichi Okazaki
Osaka, Japan
Author Affiliations: Department of Gastroenterology and Hepatology (Ikeura T, Kato K, Takaoka M, Shimatani M and Okazaki K), Department of Emergency and Critical Care Medicine (Kishimoto M), Department of Anesthesiology (Nishi K), and Department of Radiology (Kariya S), Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka 5731010, Japan
Corresponding Author: Tsukasa Ikeura, MD, PhD, Department of Gastroenterology and Hepatology, Kansai Medical University, 2-5-1, Shinmachi, Hirakata, Osaka 5731010, Japan (Tel: +81-72-804-0101; Fax:+81-72-804-2524; Email: ikeurat@hirakata.kmu.ac.jp)
Abstract：BACKGROUND: In Asian population, there is limited information on the relevance between obesity and poor outcomes in acute pancreatitis (AP). The objective of this study was to examine the clinical impact of obesity based on body mass index (BMI) on prognosis of AP in Japanese patients.
METHODS: A total of 116 patients with AP were enrolled in this study. Univariate and multivariate logistic regression analyses were performed to examine relations between BMI and patients’ outcomes. Additionally, to investigate whether including obesity as a prognostic factor improved the predictive accuracy of a Japanese prognostic factor score (PF score), a receiver-operating characteristic (ROC) curve analysis of mortality was conducted.
RESULTS: Multiple logistic regression analyses revealed that BMI ≥25 kg/m2 was associated with a significant higher mortality [odds ratio (OR)=15.8; 95% confidence interval (CI): 1.1-227; P=0.043]. The area under the ROC curve (AUC) for the combination of PF score and BMI ≥25 kg/m2 (AUC=0.881; 95% CI: 0.809-0.952) was higher than that for the PF score alone (AUC=0.820; 95% CI: 0.713-0.927) (P=0.034).
CONCLUSIONS: The negative impact of a high BMI on the prognosis of AP was confirmed in a Japanese population. Including BMI ≥25 kg/m2 as an additional parameter to PF score enhanced the predictive value of the PF score for AP-related mortality.
. [J]. Hepatobiliary Pancreat Dis Int, 2017, 16(6): 645-651.
Ikeura T, Kato K, Takaoka M, Shimatani M, Kishimoto M, Nishi K, Kariya S, Okazaki K. A body mass index ≥25 kg/m2 is associated with a poor prognosis in patients with acute pancreatitis: a study of Japanese patients. Hepatobiliary Pancreat Dis Int, 2017, 16(6): 645-651.
2017, Vol. 16 
