Involvement of the circular RNA/microRNA/glucose-6-phosphate dehydrogenase axis in the pathological mechanism of hepatocellular carcinoma
Ying Wang a , # , Xin-Yi Zhou a , # , Xiang-Yun Lu b , Ke-Da Chen a , Hang-Ping Yao b , ∗
a Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China
b State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Abstract：Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide with high mortality. The incidence of HCC is increasing in China. Abnormal activation of glucose-6-phosphate dehydrogenase (G6PD) exists in all malignant tumors, including HCC, and is closely related to the de- velopment of HCC. In addition, the differential expression of non-coding RNAs is closely related to the development of HCC. This systematic review focuses on the relationship between G6PD, HCC, and non- coding RNA, which form the basis for the circRNA/miRNA/G6PD axis in HCC. The circular RNA (cir- cRNA)/microRNA (miRNA)/G6PD axis is involved in development of HCC. We proposed that non-coding RNA molecules of the circRNA/miRNA/G6PD axis may be novel biomarkers for the pathological diagnosis, prognosis, and targeted therapy of HCC.
. [J]. Hepatobiliary Pancreat Dis Int, 2021, 20(6): 530-534.
Wang Y, Zhou XY, Lu XY, Chen KD, Yao HP. Involvement of the circular RNA/microRNA/glucose-6-phosphate dehydrogenase axis in the pathological mechanism of hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int, 2021, 20(6): 530-534.
2021, Vol. 20 
