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| Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach |
| Jongkyoung Choi, Ji Kon Ryu, Sang Hyub Lee, Dong-Won Ahn, Jin-Hyeok Hwang, Yong-Tae Kim, Yong Bum Yoon and Joon Koo Han |
Seoul, Korea
Author Affiliations: Department of Internal Medicine and Liver Research Institute (Choi J, Ryu JK, Lee SH, Ahn DW, Hwang JH, Kim YT and Yoon YB) and Department of Radiology (Han JK), Seoul National University College of Medicine, Seoul, Korea; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do, Korea (Lee SH and Hwang JH); Department of Internal Medicine, National Medical Center, Seoul, Korea (Choi J); Department of Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Korea (Ahn DW)
Corresponding Author: Sang Hyub Lee, MD, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea (Tel: 82-31-787-7042; Fax: 82-31-787-4051; Email: gidoctor@snubh.org) |
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Abstract BACKGROUND: For palliative treatment of the obstructive jaundice associated with unresectable hepatocellular carcinoma (HCC), percutaneous transhepatic biliary drainage (PTBD) or endoscopic retrograde biliary drainage (ERBD) has been performed. PTBD is preferred as an initial procedure. Little is known about the better option for patients with obstructive jaundice caused by unresectable HCC.
METHODS: Sixty patients who had received ERBD or PTBD for the palliative treatment of obstructive jaundice caused by unresectable HCC between January 2006 and May 2010 were included in this retrospective study. Successful drainage, drainage patency, and the overall survival of patients were evaluated.
RESULTS: Univariate analysis revealed that the overall frequency of successful drainage was higher in the ERBD group (22/29, 75.9%) than in the PTBD group (15/31, 48.4%) (P=0.029); but multivariate analysis showed marginal significance (P=0.057). The duration of drainage patency was longer in the ERBD group than in the PTBD group (82 vs 37 days, respectively, P=0.020). Regardless of what procedure was performed, the median survival time of patients who had a successful drainage was much longer than that of the patients who did not have a successful drainage (143 vs 38 days, respectively, P<0.001).
CONCLUSION: Besides PTBD, ERBD may be used as the initial treatment option to improve obstructive jaundice in patients with unresectable HCC if there is a longer duration of drainage patency after a successful drainage.
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2012, Vol. 11 
