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hTERT rs2736098 genetic variants and susceptibility of hepatocellular carcinoma in the Chinese population: a case-control study |
Chao Zhang, Ya-Ping Tian, Yue Wang, Feng-Hua Guo, Jun-Fang Qin and Hong Ni |
Tianjin, China
Author Affiliations: Tianjin Medical University General Hospital, Tianjin 300071, China (Zhang C); Department of Clinical Biochemistry, General Hospital of PLA, Beijing 100853, China (Tian YP); Nankai University College of Medicine, Tianjin 300071, China (Wang Y, Guo FH, Qin JF and Ni H)
Corresponding Author: Hong Ni, MD, Departmeat of Pathophysiology, Nankai University College of Medicine, Tianjin 300071, China (Tel: 86-22- 23507728; Fax: 86-22-23502554; Email: hongni@nankai.edu.cn) |
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Abstract BACKGROUND: The human telomerase reverse transcriptase (hTERT) gene encodes the catalytic subunit of telomerase, which mediates pleiotropic effects, including the regulation of senescence and proliferation and plays an important role in carcinogenesis. This study attempts to clarify the genetic predisposition to hepatocellular carcinoma (HCC), focusing on the hTERT gene rs2736098 polymorphism.
METHOD: Four hundred patients with HCC and 400 non-cancer controls were genotyped to elucidate the potential association between hTERT rs2736098 polymorphism and HCC risks.
RESULTS: Compared with the controls, the patients with HCC had a lower frequency of G/G genotype (33.3% vs 44.3%, P=0.001) and a higher frequency of G/A (51.5% vs 39.5%, P=0.001). Allele genotypic frequencies in the patients differed from those of the controls (P=0.040). The data of this study rs2736098[A] allele contributed significantly to HCC risk in female patients (OR=1.78, 95% CI, 1.17-2.72, P=0.007), patients with HCV infection (OR=2.89, 95% CI, 1.08-7.70, P=0.031), non-drinker patients (OR=1.32, 95% CI, 1.06-1.65, P=0.015), and patients not affected by HBV (OR=1.77, 95% CI, 1.30-2.40, P<0.001).
CONCLUSIONS: rs2736098[A] may be an independent here-ditary parameter in HCC, but some risk factors would cover up the association by more powerful hepatocarcinogenesis. These results are important guidance for further studies in detecting HCC-associated single nucleotide polymorphisms.
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