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| Hemodynamics and oxygen transport dynamics during hepatic resection at different central venous pressures in a pig model |
| Ya Guo, Cheng-Xin Lin, Wan-Yee Lau, Di Long, Cheng-Yi Lao, Zhang Wen, Eric CH Lai, Xi-Jun Wang, Le-Qun Li and Xiao Qing |
Nanning, China
Author Affiliations: Department of Hepatic and Biliary Surgery (Guo Y, Lau WY, Long D, Wen Z and Qing X), Department of Anesthesiology (Lin CX, Lao CY and Wang XJ), First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China; Faculty of Medicine, the Chinese University of Hong Kong, Shatin, New Territories, Hongkong SAR, China (Lau WY and Lai ECH); Department of Hepatic and Biliary Surgery, The Tumor Hospital of Guangxi Medical University, Nanning 530021, China (Li LQ)
Corresponding Author: Cheng-Xin Lin, MD, Department of Anesthesiology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China (Tel: 86-771-5356528; Fax: 86-771-5350031; Email: guoya2000@medmail.com.cn) |
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Abstract BACKGROUND: Although low central venous pressure (CVP) has been used to minimize blood loss during hepatectomy, the impact of variations of CVP on the rate of blood loss and on the perfusion of end-organs has not been evaluated. This animal study aimed to evaluate the hemodynamics and oxygen transport changes during hepatic resection at different CVP levels.
METHODS: Forty-eight anesthetized Bama miniature pigs were divided into 8 groups with CVP during hepatic resection controlled at 0 to <1, 1 to <2, 2 to <3, 3 to <4, 4 to <5, 5 to <6, 6 to <7, and 7 to <8 cmH2O. Intergroup comparisons were made for hemodynamic parameters, oxygen transport dynamics, and the rate of blood loss.
RESULTS: The rate of blood loss and the hepatic venous pressure during hepatic resection were almost linearly related to the CVP. A significant drop in the mean arterial pressure, cardiac output, and cardiac index occurred between CVP ≥2 and <2 cmH2O. Oxygen delivery (DO2), oxygen consumption (VO2) and oxygen extraction ratio (ERO2) remained relatively constant between CVPs of 2 to <8 cmH2O. There was a significant drop in DO2 when the CVP was <2 cmH2O. There was also a significant drop in VO2 and ExO2 when the CVP was <1 cmH2O.
CONCLUSION: The optimal CVP for hepatic resection is 2 to 3 cmH2O.
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2011, Vol. 10 
