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| Advances in prognostic factors in acute pancreatitis: a mini-review |
| Theodoros E Pavlidis, Efstathios T Pavlidis and Athanasios K Sakantamis |
Thessaloniki, Greece
Author Affiliations: Surgical Propedeutical Department, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Konstantinoupoleos 49, 54642 Thessaloniki, Greece (Pavlidis TE, Pavlidis ET and Sakantamis AK)
Corresponding Author: Theodoros E Pavlidis, MD, PhD, Associate Professor of Surgery, A Samothraki 23, 54248 Thessaloniki, Greece (Tel: +302310-992861; Fax: +302310-992932; Email: pavlidth@otenet.gr; pavlidth@med.auth.gr; pavlidth@auth.gr) |
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Abstract BACKGROUND: Early assessment of the severity of acute pancreatitis is essential to the proper management of the disease. It is dependent on the criteria of the Atlanta classification system.
DATA SOURCES: PubMed search of recent relevant articles was performed to identify information about the severity and prognosis of acute pancreatitis.
RESULTS: The scoring systems included the Ranson s or Glasgow s criteria ≥3, the APACHE II classification system ≥8, and the Balthazar s criteria ≥4 according to the computed tomography enhanced scanning findings. The single factors on admission included age >65 years, obesity, hemoconcentration (>44%), abnormal chest X-ray, creatinine >2 mg/dl, C-reactive protein>150 mg/dl, procalcitonin >1.8 ng/ml, albumin <2.5 mg/dl, calcium <8.5 mg/dl, early hyperglycemia, increased intra-abdominal pressure, macrophage migration inhibitory factor, or a combination of IL-10 >50 pg/ml with calcium <6.6 mg/dl.
CONCLUSION: The prediction of the severity of acute pancreatitis is largely based on well defined multiple factor scoring systems as well as several single risk factors.
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2010, Vol. 9 
