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| Preconditioning and postconditioning reduce hepatic ischemia-reperfusion injury in rats |
| Wan-Xing Zhang, Wen Yin, Lei Zhang, Lan-Hui Wang, Lei Bao, Hong-Fang Tuo, Li-Fang Zhou and Chun-Cheng Wang |
Shijiazhuang, China
Author Affiliations: Department of Hepatobiliary Surgery (Zhang WX, Yin W, Wang LH, Bao L, Tuo HF, Zhou LF and Wang CC), and Department of Pharmacy (Zhang L), Hebei Provincial General Hospital, Shijiazhuang 050051, China
Corresponding Author: Wan-Xing Zhang, MD, Department of Hepatobiliary Surgery, Hebei Provincial General Hospital, Shijiazhuang 050051, China (Tel: 86-311-85988739; Email: zhangwx12@hotmail.com) |
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Abstract BACKGROUND: Ischemia-reperfusion injury occurs when ischemic tissues or organs suffer from further functional and structural damage when their blood supply recovers. This study aimed to contrast the protective effects of ischemic preconditioning and ischemic postconditioning in hepatic ischemia-reperfusion injury in rats.
METHODS: Thirty-two healthy male Wistar rats were randomly divided into four groups: sham-operated (SO), ischemia-reperfusion (IR), ischemic preconditioning (I-pre), and ischemic postconditioning (I-post). Blood samples and hepatic tissue were taken from all groups after the experiments.
RESULTS: There were significant differences between the IR, I-pre and I-post groups in alanine aminotransferase and aspartate aminotransferase levels, NF-κB p65 expression, apoptosis index and superoxide dismutase activity in hepatic tissue. There were no significant differences between the I-pre and I-post groups.
CONCLUSIONS: Ischemic postconditioning and ischemic preconditioning reduce hepatic ischemia-reperfusion injury, but in clinical practice the former is a more appropriate choice.
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2009, Vol. 8 
