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Clinical value of contrast-enhanced ultrasonography in the characterization of focal liver lesions: a prospective multicenter trial |
Wen-Ping Wang, Ying Wu, Yan Luo, Rui Li, Xiao-Dong Zhou, Jun Zhang, Chao-Wen Qian, Xu-Yan Tan, Qing-Hua Xu, Yan Wang and Jian-Jun Yuan |
Shanghai, China
Author Affiliations: Department of Diagnostic Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China (Wang WP); Department of Ultrasound, Shenzhen People s Hospital, Shenzhen 518020, China (Wu Y); Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China (Luo Y); Department of Ultrasound, Chongqing Southwest Hospital, Chongqing 400038, China (Li R); Department of Diagnostic Ultrasound, Xijing Hospital, the Fourth Military Medical University, Xi an 710032, China (Zhou XD); Department of Electrodiagnosis, Jilin Province Cancer Hospital, Changchun 130012, China (Zhang J); Department of Ultrasound, Zhejiang Province Cancer Hospital, Hangzhou 310022, China (Qian CW); Department of Ultrasound, Jiangsu Province Cancer Hospital, Nanjing 210009, China (Tan XY); Department of Diagnostic Ultrasound, the First People s Hospital of Foshan, Foshan 528000, China (Xu QH); Department of Ultrasound, Henan Province Cancer Hospital, Zhengzhou 450003, China (Wang Y); Department of Diagnostic Ultrasound, People s Hospital of Henan Province, Zhengzhou 450003, China (Yuan JJ)
Corresponding Author: Wen-Ping Wang, MD, Department of Diagnostic Ultrasound, Zhongshan Hospital, Fudan University, Shanghai 200032, China (Tel: 86-21-64041990ext2363; Fax: 86-21-64220319; Email: wangyuwenping@ hotmail.com) |
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Abstract BACKGROUND: Contrast-enhanced ultrasonography (CEUS) is increasingly accepted in clinical settings for diagnostic imaging of focal liver lesions (FLLs). This study aimed to assess the efficacy of CEUS in the characterization of FLLs in comparison with final diagnosis based on gold standard assessment.
METHODS: The study was approved by the local ethics committee and participating patients provided written informed consent. A total of 148 patients with 164 FLLs were studied. Unenhanced ultrasonography (US) and CEUS were performed using fundamental and harmonic imaging, respectively. Contrast enhancement was assessed during the arterial, portal and late vascular phases after intravenous administration of contrast (SonoVue®, Bracco, Italy). Sensitivity, specificity and diagnostic accuracy of US and CEUS were compared in identifying the lesion as benign, malignant or indeterminate and its actual tumor type. Final diagnosis was established by biopsy (129/164), MR imaging (11/164) or medical history (24/164).
RESULTS: When compared to the gold standard, the number of indeterminate diagnoses was reduced from 56.7% (93/164) as assessed by fundamental imaging to 6.1% (10/164) after SonoVue® enhanced US examination. Sensitivity and specificity improved from 49% and 25% at baseline US to 93% and 75% with CEUS, respectively (P<0.01). Diagnostic accuracy of CEUS was 88% in contrast to 41% of baseline US.
CONCLUSION: SonoVue® enhanced US improves the characterization of FLLs and may limit the need for further investigations.
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Cite this article: |
Wang WP,
Wu Y,
Luo Y,
et al.
Clinical value of contrast-enhanced ultrasonography in the characterization of focal liver lesions: a prospective multicenter trial.
Hepatobiliary Pancreat Dis Int
2009;
8(4):
370-376. DOI:
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URL: |
http://dx.doi.org/ OR http://www.hbpdint.com/EN/Y2009/V8/I4/370 |
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