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| Bortezomib in treatment of extramedullary plasmacytoma of the pancreas |
| Ju-Ying Wei, Hong-Yan Tong, Wei-Fang Zhu, Hui Liu, Feng-Juan Zhang, Wen-Juan Yu and Jie Jin |
Hangzhou, China
Author Affiliations: Department of Hematology (Wei JY, Tong HY, Liu H, Zhang FJ, Yu WJ and Jin J), and Department of Dermatology (Zhu WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Corresponding Author: Hong-Yan Tong, MD, Department of Hematology, Institute of Hematology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Tel: 86-571-87236898; Fax: 86-571-87236702; Email: hongyantong@yahoo.com.cn) |
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Abstract BACKGROUND: Extramedullary pancreatic plasmacy-toma treated with bortezomib is rarely reported.
METHODS: We admitted a 53-year-old woman with an asymptomatic mass above the left clavicle for over three months, then an asymptomatic swelling of the pancreas was found. A biopsy on the mass and a fine needle aspiration of the pancreas were performed. The diagnosis of extramedullary plasmacytoma (EMP) was made. The patient was initially treated with combination chemotherapy consisting of vincristine, doxorubicin and dexamethasone (VAD regimen). She progressed to painless jaundice during the chemotherapy. Then she was treated with bortezomib and hyper-dose dexamethasone. As a result, she had a near complete remission.
RESULTS: The data demonstrated that the diagnosis was EMP of the pancreas. The patient responded very well to bortezomib, while failing to respond to the traditional chemotherapy regimen of VAD.
CONCLUSION: EMP of the pancreas is rare. This case gives evidence for an excellent response of EMP of the pancreas to bortezomib.
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2009, Vol. 8 
