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| Efficacy and safety of moderately steatotic donor liver in transplantation |
| Feng Gao, Xiao Xu, Qi Ling, Jian Wu, Lin Zhou, Hai-Yang Xie, Hui-Ping Wang and Shu-Sen Zheng |
Hangzhou, China
Author Affiliations: Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Gao F, Xu X, Ling Q, Wu J, Zhou L, Xie HY, Wang HP and Zheng SS)
Corresponding Author: Shu-Sen Zheng, MD, PhD, FACS, Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Tel: 86-571-87236567; Email: zyzss@zju.edu.cn) |
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Abstract BACKGROUND: The discrepancy between available livers and requests for transplantation has forced many centers to use marginal donors in order to expand the donor pool. Many previous studies have demonstrated controversial results of the application of steatotic liver grafts. The aim of the present study was to summarize our experience and evaluate the value of steatotic liver grafts.
METHODS: The clinical and follow-up data of 24 adult patients receiving moderately steatotic liver grafts (30%-60%) from May 2003 to June 2005 (group 1) were analyzed. After matching for age, gender, model for end-stage liver diseases score and cold ischemia time, another 24 patients receiving liver grafts with steatosis less than 30% were chosen as the control group (group 2). The patient and graft outcomes were compared between the two groups.
RESULTS: No difference of liver and kidney functions in the first post-transplant week was found between the two groups (P>0.05). Neither the incidence of early allograft dysfunction and acute kidney injury nor the patient survival rates (3 months, 6 months and 1 year) showed differences between groups 1 and 2 (P>0.05).
CONCLUSION: Moderately steatotic liver grafts provide adequate function in the first phase after transplantation and can be used for transplantation.
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2009, Vol. 8 
