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Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents |
Dong-Mei Guo, Tian-Shuang Qiu, Jie Bian, Shu-Feng Liu and Chang-Zheng Wang |
Dalian, China
Author Affiliations: Department of Electronic Engineering, Dalian University of Technology, Dalian 116024, China (Guo DM and Qiu TS); Department of Radiology, Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China (Guo DM, Bian J and Liu SF); Department of Radiology, People Hospital of Lvshun District, Dalian 116041, China (Wang CZ)
Corresponding Author: Tian-Shuang Qiu, PhD, Department of Electronic Engineering, Dalian University of Technology, Dalian 116024, China (Email: qiutsh@dlut.edu.cn) |
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Abstract BACKGROUND: Gadolinium-enhanced multi-phase dynamic imaging has improved the accuracy of the diagnosis of hypervascular hepatocellular carcinoma (HCC), but using gadolinium-enhanced dynamic imaging alone is problematic in evaluating hypovascular HCC. This work aimed at evaluating the combined use of superparamagnetic iron oxide (SPIO)-enhanced and gadolinium set in distinguishing HCCs from regenerative nodules (RNs) in a rat model induced by diethylnitrosamine (DEN).
METHODS: DEN-induced HCC model rats (n=40) and control rats (n=10) were studied. From weeks 16 to 19 after DEN administration, 4 animals were scanned every week. The hepatic changes were tested with a 1.5 Tesla magnet, and MR images of SPIO-enhanced and gadolinium set were obtained. According to the pathologic changes, the tumorigenesis was divided into HCC and RN (diameter of nodules ≥3 mm). Diagnostic accuracy of the combined SPIO-enhanced and gadolinium set and the gadolinium set alone was evaluated using receiver-operating characteristic curves. Sensitivity and specificity of the combined SPIO-enhanced and gadolinium set and the gadolinium set alone were calculated.
RESULTS: The listed tests were completed in 29 rats (21 treated and 8 controls). One hundred and six nodules (82 HCCs, 24 RNs) were analyzed. The Az value and sensitivity with the combined SPIO-enhanced and gadolinium set (Az 0.94, sensitivity 0.96) were higher than those with the gadolinium set alone (Az 0.92, sensitivity 0.89). Using the combined SPIO-enhanced and gadolinium set led to detection of 6 nodules which were negative in the gadolinium set alone and 3 nodules were correctly characterized.
CONCLUSION: Using the combined SPIO-enhanced and gadolinium set improved the detectability of HCCs and the SPIO-enhanced imaging compensated for the gadolinium set in differentiating HCCs from RNs in a rat model.
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Cite this article: |
Guo DM,
Qiu TS,
Bian J,
et al.
Detection and characterization of hepatocellular carcinoma in rats with liver cirrhosis: diagnostic value of combined use of MR positive and negative contrast agents.
Hepatobiliary Pancreat Dis Int
2009;
8(1):
65-70. DOI:
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URL: |
http://dx.doi.org/ OR http://www.hbpdint.com/EN/Y2009/V8/I1/65 |
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