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| Assessment of cardiac output in liver transplantation recipients |
| Tomohide Hori, Chiduru Yamamoto, Shintaro Yagi, Taku Iida, Kentaro Taniguchi, Takashi Hasegawa, Koichiro Yamakado, Yukinobu Hori, Kan Takeda, Kazuo Maruyama and Shinji Uemoto |
Kyoto, Japan
Author Affiliations: Department of Hepato-Pancreato-Biliary Surgery and Transplantation, Kyoto University Hospital, 54 Shogoinkawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan (Hori T, Yagi S and Iida T); Department of Hepatobiliary Pancreatic Surgery, Mie University Hospital, 2-174 Edobashi, Tsu City, Mie Prefecture, 514-8507, Japan (Yamamoto C, Taniguchi K and Uemoto S); Department of Anesthesiology and Critical Care Medicine (Hasegawa T and Maruyama K) and Department of Radiology (Yamakado K and Takeda K), Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie Prefecture, 514-8507, Japan; Nagoya Economic University Graduate School of Law, 61-1 Uchikubo, Inuyama City Aichi Prefecture, 484-8504, Japan (Hori Y)
Corresponding Author: Tomohide Hori, MD, PhD, Department of Hepato-Pancreato-Biliary Surgery and Transplantation, Kyoto University Hospital, 54 Shogoinkawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan (Tel: 81-75-751-3651; Fax: 81-75-751-3106; Email: horit@kuhp.kyoto-u.ac.jp) |
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Abstract BACKGROUND: Liver cirrhosis causes peculiar systemic hemodynamics, and accurate evaluation of systemic hemodynamic state is important for cirrhotic recipients who underwent living donor liver transplantation (LDLT). We investigated the clinical advantages of a novel non-invasive method for measuring systemic hemodynamic parameters using indocyanine green (ICG).
METHODS: Twenty-eight LDLT recipients were evaluated. Simultaneous measurements of cardiac output (CO) using Swan-Ganz catheters and pulse dye densitometry (PDD) were performed every 12 hours after LDLT. A total of 155 sets of simultaneous CO measurements were obtained.
RESULTS: The CO values obtained by PDD correlated well with those obtained by the invasive catheter technique. In addition, none of the recipients developed any side-effects, and we verified the safety of repeated ICG injections. ICG is safe, even for repeated use over time in the same recipient. Moreover, PDD can measure the blood volume (BV).
CONCLUSIONS: Since the cirrhotic systemic hemody-namics characterized by high CO and large BV remains, even after LDLT, the ability to measure CO and BV in a non-invasive, simple and real-time manner using PDD has advantages for cirrhotic LDLT recipients.
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2008, Vol. 7 
