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| The roles of serum IL-18, IL-10, TNF-α and sIL-2R in patients with chronic hepatitis C |
| Hong-Yu Jia, Jie Du, Si-He Zhu, Ying-Ji Ma, Huan-Yong Chen, Bao-Shan Yang, Hua-Feng Cai |
From the Departments of Infectious Diseases (Jia HY, Zhu SH, Ma YJ, Chen HY, Yang BS and Cai HF) and Pharmacy (Du J), First Clinical College, Harbin Medical University, Harbin 150001, China
Correspondence: Hong-Yu Jia, MD (Tel: 86-451-3641918ext5357; Email: jia_hy@sohu.com) |
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Abstract Objective: To identify the roles of serum IL-18, IL-10, TNF-α and sIL-2R in the pathogenisis of chronic hepatitis C and the effects of interferon on the mentioned serum cytokines.
Methods: The levels of IL-18, IL-10, TNF-α and sIL-2R were detected in 10 healthy controls, 24 asymptomatic HCV carriers, and 27 patients with chronic hepatitis C (before and after IFN treatment) by enzyme linked immunosorbent assay (ELISA).
Results: The levels of IL-18, IL-10, TNF-α and sIL-2R in the patients of chronic hepatitis C were higher than those in the healthy controls (P＜0.05＝ and in asymptomatic HCV carriers (P＜0.05＝. The values of the mentioned cytokines showed a significant positive correlation to GPT. The levels of the mentioned cytokines decreased obviously after IFN treatment (P＜0.05＝, while the serum levels of IL-10 and sIL-2R reduced in sequence in no-response group, partial-response group and complete-response group.
Conclusions: IL-18, IL-10, TNF-α and sIL-2R co-participate in the pathogenisis of chronic hepatitis C, and are used to evaluate the effect of IFN on the immune state of organisms, and IL-10 and sIL-2R are important for predicting the anti-viral efficacy of IFN.
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2002, Vol. 1 
