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| Expressions of vascular endothelial growth factor in cirrhotic tissues and their relations to proto-oncogene c-fos, c-myc |
| Bao-Min Shi, Xiu-Yan Wang, Qing-Ling Mu, Tai-Huang Wu, Zhen Yang, Li Zhang and Da-Peng Li |
From the Department of General Surgery, Shandong Provincial Hospital, Jinan 250021, China (Shi BM, Wang XY, Mu QL, Wu TH); Department of General Surgery, Tongji Hospital, Tongji Medical University, Wuhan 430030, China (Yang Z, Zhang L and Li DP)
Correspondence: Bao-Min Shi, MD (Tel: 86-531-7938911ext2363; Fax: 86-531-7937741; Email: baomins@163.net) |
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Abstract Objective: To investigate the significance of vascular endothelial growth factor (VEGF) in the pathogenesis of liver cirrhosis and the correlation between VEGF and proto-oncogene c-fos and c-myc in cirrhotic liver.
Methods: The proteins of VEGF, c-fos, and c-myc were identified immunohistochemically in each tissue section of 53 cases of liver cirrhosis. The correlations between VEGF, c-fos and c-myc were analyzed. The levels of VEGF protein in different Child gradings were also compared.
Results: The proteins of VEGF were more highly expressed in Child A and B patients than in Child C patients and controls. The expressions of both c-fos and c-myc were not statistically significant between VEGF positive and negative patients.
Conclusions: The protein level of VEGF can reflect the compensation status of cirrhosis patients and may act as an anti-cirrhotic factor. The proto-oncogene c-fos, c-myc and VEGF may have different mechanisms in the course of cirrhosis or hepatic tumorigenesis.
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| Cite this article: |
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Shi BM,
Wang XY,
Mu QL,
et al.
Expressions of vascular endothelial growth factor in cirrhotic tissues and their relations to proto-oncogene c-fos, c-myc.
Hepatobiliary Pancreat Dis Int
2002;
1(3):
388-391. DOI:
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| URL: |
| http://dx.doi.org/ OR http://www.hbpdint.com/EN/Y2002/V1/I3/388 |
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2002, Vol. 1 
