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| Drug resistance of infectious pathogens after liver transplantation |
| Jian-Dang Zhou, Jian-Jun Guo, Qin Zhang, Yin Chen, Shai-Hong Zhu and Huai-Yan Peng |
Changsha, China
Author Affiliations: Department of Clinical Laboratory (Zhou JD, Guo JJ, Chen Y and Peng HY), Institute of Organ Transplantation (Zhu SH), the Third Xiangya Hospital of Central South University; Department of Medical Laboratories (Zhang Q), College of Medical Technology and Information of Central South University, Changsha 410013, China
Corresponding Author: Jian-Dang Zhou, MD, Department of Clinical Laboratory, the Third Xiangya Hospital of Central South University, Changsha 410013, China (Tel: 86-731-8618439; Fax: 86-731-8618627; Email: jiandangzhou@126.com) |
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Abstract BACKGROUND: Infection in liver recipients is related to high risk of transplantation failure and mortality. Infectious agents isolated from 55 liver recipients from January 2003 through June 2005 were studied to improve the anti-infectious therapy.
METHODS: Pathogens were isolated from routine culture. K-B method was used to examine the drug susceptibility. Extended spectrum β-lactamase, AmpC β-lactamase and Van gene in E. coli were examined by the agar-dilution susceptibility test and Nitrocefin test.
RESULTS: Thirty-nine of the 55 recipients got infection. The 513 strains of pathogens isolated from 1861 specimens were predominantly Gram negative bacteria and over 40% of them showed resistance to more than 4 drugs. The positive rates of extended spectrum β-lactamse and AmpC β-lactamse production in E.cloacae were 32.4% and 36.8%, in E.coli were 33.8% and 10.5%, but the rates of these 2 bacteria producing both lactamses were 24.3% and 7.0%. The β-lactamse production rates of Enterococcus faecalis and Enterococcus faecium were 8.8% and 11.1%, and the resistance rates to vancomycin were 11.2% and 18.5%, respectively.
CONCLUSIONS: Infectious pathogens isolated from liver recipients are potent and multiple drug resistant. ESBLs and AmpC β-lactamases are the major factors associated with Gram negative drug resistance. The infection of Enterococcal species presents as a particular challenge.
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2006, Vol. 5 
