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Metastatic clear cell variant of hepatocellular carcinoma with an occult hepatic primary |
Samir Shah, Sudeep Gupta, Tanuja Shet, Amita Maheshwari, Rekha Wuntkal and Kunisshery Mallath Mohandas |
Mumbai, India
Author Affiliations: Department of Medical Oncology, Tata Memorial Hospital, Mumbai 400012, India (Shah S, Gupta S, Shet T, Maheshwari A, Wuntkal R and Mohandas KM)
Corresponding Author: Sudeep Gupta, MD, Room No. 15, Main Building, Tata Memorial Hospital, Parel, Mumbai 400012, India (Tel: 91-22-24177201; Fax: 91-22-24165449; Email: sudeepgupta04@yahoo.com) |
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Abstract Metastatic clear cell carcinomas are commonly seen in the kidney and lung. Clear cell variant of hepatocellular carcinoma is an uncommon tumour. Diagnosis is usually made by correlation of histopathology, tumour markers and immunohistochemistry, especially HepPar 1. In this unusual case of metastatic clear cell carcinoma presenting as Sister Mary Joseph’s nodule, no primary evidence was observed radiologically in the liver, but the level of alfa fetoprotein was markedly elevated. Metastatic clear cell carcinoma of the liver with an occult hepatic primary was diagnosed by immunohistochemical profile of the tumour.
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