|
|
CT assessment of liver hemodynamics in patients with hepatocellular carcinoma after argon-helium cryoablation |
Xue-Jia Hao, Jin-Ping Li, Hui-Jie Jiang, Da-Qing Li, Zai-Sheng Ling, Li-Ming Xue and Guang-Long Feng |
Harbin, China
Author Affiliations: Department of Radiology, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China (Hao XJ, Li JP, Jiang HJ, Li DQ, Ling ZS, Xue LM and Feng GL)
Corresponding Author: Hui-Jie Jiang, MD, PhD, Department of Radiology, Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China (Tel: 86-451-86605576; Email: jhjemail@163.com) |
|
|
Abstract BACKGROUND: Assessment of tumor response after argon-helium cryoablation is critical in guiding future therapy for unresectable hepatocellular carcinoma. This study aimed to evaluate liver hemodynamics in hepatocellular carcinoma after argon-helium cryoablation with computed tomography perfusion.
METHODS: The control group comprised 40 volunteers without liver disease. The experimental group was composed of 15 patients with hepatocellular carcinoma treated with argon-helium cryoablation. Computed tomography perfusion parameters were measured: hepatic blood flow, hepatic blood volume, mean transit time, permeability of capillary vessel surface, hepatic arterial fraction, hepatic arterial perfusion, and hepatic portal perfusion.
RESULTS: After treatment, in the tumor foci, permeability of capillary vessel surface was higher, and hepatic blood flow, hepatic blood volume, hepatic arterial fraction, and hepatic arterial perfusion values were lower (P<0.05). In the liver parenchyma surrounding the tumor, hepatic arterial perfusion was significantly lower (P<0.05); however, there was no significant difference in hepatic blood flow, hepatic blood volume, mean transit time, permeability of capillary vessel surface, hepatic arterial fraction, or hepatic portal perfusion (P>0.05).
CONCLUSION: Computed tomography perfusion can evaluate tumor response after argon-helium cryoablation.
|
|
|
|
|
|
|
|