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| Detection of liver micrometastases from colorectal origin by perfusion CT in a rat model |
| Caroline Hatwell, Magaly Zappa, Mathilde Wagner, Nicolas Michoux, Valérie Paradis, Valérie Vilgrain, Léon Maggiori and Yves Panis |
Clichy, France
Author Affiliations: Department of Colorectal Surgery (Hatwell C, Maggiori L and Panis Y), Department of Radiology (Zappa M, Wagner M, Michoux N and Vilgrain V), and Department of Pathology (Paradis V), Beaujon Hospital (AP-HP), 100 boulevard du Général Leclerc, 92118 Clichy, France; Research Unit Bichat-Beaujon, INSERM U773, Université Paris VII (Denis Diderot), Paris, France (Hatwell C, Wagner M, Michoux N, Paradis V, Vilgrain V, Maggiori L and Panis Y)
Corresponding Author: Professor Yves Panis, MD, PhD, Service de Chirurgie Colorectale, Pôle des Maladies de l'Appareil Digestif, Hôpital Beaujon – Assistance Publique des Hôpitaux de Paris (AP-HP), Université Paris VII (Denis Diderot), 100 boulevard du Général Leclerc, 92118 Clichy, France (Tel: 33-01-40874547; Fax: 33-01-40874431; Email: yves.panis@bjn.aphp.fr) |
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Abstract BACKGROUND: Some patients with colorectal carcinoma have liver metastases (LMs) which cannot be detected by conventional imaging. This study aimed to assess whether hepatic perfusion changes induced by micrometastases can be detected by perfusion computed tomography (CT).
METHODS: LMs were produced in rats by injecting carcinoma cells into the portal vein. Perfusion CT was performed at microscopic (day 10), interval (day 17), and macroscopic stage (day 34). Perfusion parameters were computed using a dual-input one-compartmental model.
RESULTS: Micro and macro LMs presented a mean diameter of 0.5 and 2.6 mm, respectively. Compared to controls, LMs at interval (1.1 mm) and macroscopic stage induced significant perfusion changes: a decrease of 42% (P=0.004) and 41% (P=0.029) in hepatic transit time and an increase of 292% (P=0.073) and 240% (P=0.001) in portal delay, respectively.
CONCLUSIONS: LMs with a mean diameter between 1.1 and 2.6 mm induced significant hepatic perfusion changes, detected by CT. Such detection may help to select patients and propose chemotherapy at the time of primary tumor resection.
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2014, Vol. 13 
