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| Diagnostic yield of EUS-FNA of small (≤15mm) solid pancreatic lesions using a 25-gauge needle |
| Stefano Francesco Crino a,∗, Maria Cristina Conti Bellocchi a, Laura Bernardoni a, Erminia Manfrin b, Alice Parisi b, Antonio Amodio a, Nicolò De Pretis a, Luca Frulloni a, Armando Gabbrielli a |
a Gastroenterology and Digestive Endoscopy Unit, The Pancreas Institute, University of Verona, G.B. Rossi University Hospital, 11 P.le L.A. Scuro 10, Verona
37134, Italy
b Department of Pathology, University of Verona, G.B. Rossi University Hospital, 11 P.le L.A. Scuro 10, Verona 37134, Italy
∗ Corresponding author.
E-mail address: stefanofrancesco.crino@ospedaleuniverona.it (S.F. Crino). |
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Abstract Background: Early detection of small solid pancreatic lesions is increasingly common. To date, few and contradictory data have been published about the relationship between lesion size and endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) diagnostic yield. The aim of this study was to assess the relation between the size of solid pancreatic lesions and the diagnostic yield of EUS-FNA using a 25-gauge needle in a center without available rapid on-site evaluation.
Methods: In the retrospective cohort study, we selected patients who underwent EUS-FNA for solid pancreatic lesions with a 25-gauge needle from October 2014 to October 2015. Patients were divided into three groups (≤15mm, 16–25mm and >25 mm), and the outcomes were compared.
Results: We analyzed 163 patients. Overall adequacy, sensitivity, specificity and accuracy were 85.2%, 81.8%, 93.7%, and 80.4%, respectively. When stratified by size, the sensitivity and accuracy correlated with size (P=0.016 and P=0.042, respectively). Multivariate analysis showed that lesion size was the only independent factor (P=0.019, OR=4.76) affecting accuracy. The role of size as an independent factor affecting accuracy was confirmed in a separate multivariate analysis, where size was included in the model as a covariate (P=0.018, OR=1.08).
Conclusion: Our study demonstrates that, in the absence of rapid on-site evaluation, mass size affects the accuracy of EUS-FNA of solid pancreatic lesions.
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2018, Vol. 17 
