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Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats: What we know so far? |
Antonios Athanasiou a,∗, Eleftherios Spartalis b, Mairead Hennessy c, Michael Spartalis b, Demetrios Moris d, Christos Damaskos b, Emmanouil Pikoulis e |
a Department of Upper Gastrointestinal Surgery, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
b Laboratory of Experimental Surgery and Surgical Research, University of Athens, Medical School, Ag. Thoma 15B, Athens 11527, Greece
c Department of Surgery, Wexford General Hospital, Ireland
d Department of Surgery, Duke University, Durham, NC, USA
e First Surgery Department, Laikon General Hospital, National and Kapodistrian University of Athens, Greece
∗Corresponding author.
E-mail address: antonios.athanasiou@uhb.nhs.uk (A. Athanasiou) |
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Abstract To the editor:
We read with great interest the article entitled "Comparativestudy of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al. [1].The aim of this study was to analyse the impact of terlipressin versus splenectomy on postoperative liver function and liver regeneration in rats undergoing 70% partial hepatectomy. Ulmer and his colleagues concluded that neither the administration of terlipressin nor splenectomy improved liver regeneration after 70% partial hepatectomy in rats. This is a very interesting research in our understanding regarding the study of postoperative liver failure and liver regeneration after modulation of portal vein pressure. However, there are some questions which demand further consideration.
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