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| Noninvasive diagnosis of nonalcoholic steatohepatitis: Emerging approaches |
| Qin Pan a , Jian-Gao Fan a , b , c , ∗ |
a Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China
b Department of Pediatric Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
c Shanghai Key Laboratory of Children’s Digestion and Nutrition, Shanghai 200092, China
∗ Corresponding author at: Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China.
E-mail address: fanjiangao@xinhuamed.com.cn (J.-G. Fan). |
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Abstract Nonalcoholic steatohepatitis (NASH), a severe type of nonalcoholic fatty liver disease (NAFLD), progresses toward liver fibrosis/cirrhosis, liver failure, and furthermore, hepatocellular carcinoma (HCC) [1]. The pathological manifestations are hepatocyte steatosis (> 5%), lobular inflammation, and ballooning degeneration, with or without fibrogenesis [2]. NAFLD/NASH results from sedentary life style, western diet, and obesity. We have witnessed the conversion of spectrum of chronic liver diseases from viral hepatitis as the leading cause to NAFLD/NASH worldwide [3]. Diagnosis of NASH is therefore of great importance for the clinical management, evaluation, and follow-up.
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2019, Vol. 18 
