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| Clinicopathological features and prognosis of surgical resected cases of biliary cancer with pancreaticobiliary maljunction |
| Tsukasa Takayashiki a , Hideyuki Yoshitomi a , Katsunori Furukawa a , Satoshi Kuboki a , Masaru Miyazaki a , b , Masayuki Ohtsuka a , ∗ |
a Department of General Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-0856, Japan
b Department of Gastroenterological Surgery, Mita Hospital, International University of Health and Welfare, 1-4-3 Mita, Minato-ku, Tokyo 108-8329, Japan
∗ Corresponding author.
E-mail address: otsuka-m@faculty.chiba-u.jp (M. Ohtsuka). |
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Abstract Pancreaticobiliary maljunction (PBM) is a congenital anomaly in which the pancreatic and bile ducts join anatomically outside of the duodenal wall away from the Oddi’s sphincter. This condition causes the reflux of pancreatic juice into the bile duct under high pressure, resulting in various pathologic changes. The features of PBM patients are common bile duct dilatation, long common channel, and high amylase levels in bile juice. Among them, one of the most significant problems is the development of biliary cancer, including extrahepatic bile duct and gallbladder cancers [1] . A nationwide survey in Japan reported biliary cancer in 21.6% of adult patients with PBM concomitant with congenital biliary dilatation, 32.1% and 62.3% extrahepatic bile duct and gallbladder cancers, respectively [2] . The problems of PBM were previously considered to be relatively specific in Asia because the number of Asian patients with PBM is greater than that of Western patients. However, a recent French multicenter study reported that the therapeutic implications and guidelines of the Japanese PBM study group were applicable to the European population [3] , suggesting that the high risk of biliary cancer in patients with PBM is an important issue in not only Asia but also Western countries.
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2020, Vol. 19 
