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The effect of SphK1/S1P signaling pathway on hepatic sinus microcirculation in rats with hepatic ischemia-reperfusion injury |
Li-Ming Jin a , b , c , Yuan-Xing Liu a , b , Jian Cheng c , Lin Zhou a , b , Hai-Yang Xie a , b , Xiao-Wen Feng a , b , Hui Li a , b , Yan Shen a , b , Xiao Xu a , b , Shu-Sen Zheng a , b , ∗ |
a Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou
310003, China
b NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China
c Department of General Surgery, Hepatobiliary and Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People’s Hospital, Affiliated
People’s Hospital of Hangzhou Medical College, Hangzhou 310014, China
∗ Corresponding author at: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine; NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China.
E-mail address: shusenzheng@zju.edu.cn (S.-S. Zheng). |
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Abstract Hepatic ischemia-reperfusion (I/R) injury is the component of liver injury related to liver transplantation and liver surgery [1–3 ]. The hepatic sinus microcirculation injury is a central part of hepatic I/R injury, which eventually leads to hepatocyte injury. This process is closely associated with the participation of liver nonparenchymal cells such as Kuffer cells, hepatic stellate cells, liver sinusoidal endothelial cells (LSECs), and cytokines. The activated LSECs and ischemic hepatocytes generate oxygen free radicals, promote cell adhesion, hinder hepatic sinus microcirculation, and damage the hepatocytes eventually [4,5]. These in turn inhibit the activation of LSECs, improving hepatic sinus microcirculation during hepatic I/R injury. Recent studies have shown that sphingosine 1-phosphate (S1P), one of the sphingolipid metabolites, has anti-apoptotic, anti-inflammatory properties and counteracts hepatic I/R injury [6,7]. Hence, this study was to investigate the protective mechanisms of LSECs in hepatic I/R injury through SphK1/S1P signaling.
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