|
|
|
| Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas mimicking pancreatic pseudocyst |
| Emina Talakic a , Jasminka Igrec a , Ann-Katrin Kaufmann-Buhler a , Elmar Janek a , Sygulla Stephan b , Peter Schemmer c , ∗, Michael Fuchsjager a |
a Division of General Radiology, Department of Radiology, Medical University of Graz, Graz, Austria
b Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria
c General, Visceral and Transplant Surgery, Department of Surgery, Medical University of Graz, Graz, Austria
∗ Corresponding author.
E-mail address: peter.schemmer@medunigraz.at (P. Schemmer). |
|
|
|
|
Abstract Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC) is one of eight histological subtypes of pancreatic ductal adenocarcinoma (PDAC) according to the 2019 WHO classification [1] . It accounts for < 1% of exocrine pancreatic carcinomas. This rare variant occurs in slightly younger patients than conventional PDAC, with a slight female predominance (male:female,7:10). On imaging, UC-OGC appears as a large cystic-solid mass with areas of hemorrhage and necrosis. Thus, they may potentially resemble pancreatic pseudocysts. Given the rarity of this variant, the prognosis is unclear, with reports of a median survival of 11 months for unresectable tumors on the one hand, and long-term survival > 5 years on the other hand. Mucinous cystic neoplasms are predisposing factors for their development in 20% of the cases. Common clinical signs and symptoms include abdominal pain, weight loss, and jaundice, but UC-OGC tends to be asymptomatic in early stages. We reported one rare case of UC-OGC together with a review of previously published cases in English language using the search term “undifferentiated carcinoma osteoclastic giant cell pancreas”.
|
|
|
|
|
|
|
|
|
2022, Vol. 21 
