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| Clinical strategies to improve the survival rate of liver recipients with
acute-on-chronic liver failure |
| Jia Yao a , b , # , Yun-Guo Lei a , b , # , Hui-Min Yi c , Yang Yang a , b , ∗ |
a Department of Hepatic Surgery, Liver Transplantation Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
b Guangdong Key Laboratory of Liver Disease Research, Guangzhou 510630, China
c Surgical Intensive Care Unit, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China
∗ Corresponding author at: Surgical Intensive Care Unit, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
E-mail address: yysysu@163.com (Y. Yang) .
# Contributed equally. |
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Abstract There are currently more than 100 million patients with liver disease in China, and 300000 patients are estimated to be diagnosed with end-stage liver diseases each year. Since Dr. Starzl, a professor from the University of Pittsburgh, completed the first liver transplant in 1963, liver transplantation has been recognized as the only effective treatment for patients with end-stage liver disease. Liver transplantation has progressed rapidly in China recently in terms of surgical techniques and perioperative management. China now is the second largest liver transplantation country in the world, with 5000-6000 liver transplantations each year. It has been reported that 24423 adult patients underwent liver transplantation in China between 2015 and 2020 [1]. However, according to the database of China Liver Transplant Registry (CLTR) in 2020, the 1- and 5-year survival rates were 84% and 71%, and were 93.6% and 81.2% in the USA in the same time period in the United Network for Organ Sharing/Organ Procurement and Transplantation Network (UNOS/OPTN) [2,3]. Therefore, there is still a room to improve in China.
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2023, Vol. 22 
