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Hypoxic hepatitis in children after cardiac surgery |
Xia-Di Zhao a , # , Jing Ye a , # , Yi-Kan Sun b , # , Jian-Feng Liang c , Lei Hu a , Anthony C. Chang d , Li-Zhong Du a , e , Hao-Min Li f , Qiang Shu e , g , Xi Chen e , h , Lin-Hua Tan a , ∗ |
a Department of Surgical ICU, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
b Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia
c Department of Medical Statistics, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
d Children’s Hospital of Orange County, Pediatric Heart Institute, Orange, CA 92868, USA
e Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, Hangzhou 310052, China
f Department of Clinical Data Center, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
g Department of Cardiac Surgery, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
h Department of Central Laboratory, Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China
∗ Corresponding author.
E-mail address: chtlh@zju.edu.cn (L.-H. Tan).
# Contributed equally. |
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Abstract Hypoxic hepatitis (HH), also known as ischemic hepatitis or shock liver, is a liver injury characterized by necrosis of centrilobular hepatocytes with a rapid increase in serum aminotransferase levels. The incidence rate of HH among patients in the intensive care unit (ICU) was found to be 0.9%-11.9% [1]. Occurrence of HH appears to have a significant impact on the clinical outcome. The 30-day mortality rate in critically ill patients who developed HH has been reported to be over 50% [1,2]. Nevertheless, raised aminotransferase levels are still not given sufficient consideration in the clinical context. The high incidence and the strong prognostic impact of HH on ICU survival encourage research to recognize its occurrence as early as possible [3].
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