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| Mechanism of hepatocytes differentiation and dedifferentiation in liver regeneration: Process and exploration |
| Zhangyuting He a , Hua-Yu Yang b , ∗ |
a Peking Union Medical College, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
b Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
∗ Corresponding author.
E-mail address: dolphinyahy@hotmail.com (H.-Y. Yang). |
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Abstract The liver has roles in many processes, including metabolism, synthesis, and biotransformation. It is unique among all visceral organs, as it even can regenerate after injury. A common research model of liver regeneration is the 2/3 partial hepatectomy (PHx) model in animals, like rodents, in which the left lateral, left medial, and right medial hepatic lobes are surgically removed [1]. Moreover, with the ability of hepatocyte hypertrophy and hyperplasia, within 7-10 days, the rest liver regenerates to its original size [2]. Jo and colleagues [3] reported that splanchnic vasoactive agents could decrease portal vein pressure to facilitate the liver regeneration after 70% hepatectomy. However, liver regeneration and function maintenance need adequate mass of future remnant liver. Inadequate mass of future remnant liver results in liver failure which loses the opportunity for the liver to regenerate and therefore, it is important to keep an adequate future remnant liver to avoid posthepatectomy liver failure [4].
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2023, Vol. 22 
