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Isolated IgG4-associated autoimmune hepatitis or the first manifestation of IgG4-related disease? |
Carmela Cosentino a , # , Daniel Clayton-Chubb a , b , # , ∗, Catriona McLean c , Stuart K Roberts a , b , William Kemp a , b |
a Department of Gastroenterology and Hepatology, Alfred Health, Melbourne 3004, VIC, Australia
b Central Clinical School, Monash University, Melbourne 3004, VIC, Australia
c Department of Anatomical Pathology, Alfred Health, Melbourne 3004, VIC, Australia
∗ Corresponding author at: Department of Gastroenterology and Hepatology, Alfred Health, Melbourne 3004, VIC, Australia.
E-mail address: d.clayton-chubb@alfred.org.au (D. Clayton-Chubb).
# Contributed equally. |
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Abstract Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (IgG4-AIH) is a novel and rare disease entity, characterized by significant infiltration of IgG4-expressing plasma cells in the liver. The classification of of IgG4-AIH as a subtype of AIH or an early manifestation of IgG4-related disease (IgG4-RD) remains controversial. Herein, we discuss an interesting clinical vignette of IgG4-AIH in a gentleman with no significant past medical history, who presented with undifferentiated symptoms and elevated aminotransferases.
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