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Wnt/beta-catenin signaling inhibitors and nonalcoholic fatty liver disease: Potential therapeutic implications |
Stergios A Polyzos a , ∗, Jannis Kountouras b , Athanasios D Anastasilakis c , Evangelos Terpos d |
a First Laboratory of Pharmacology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Macedonia, Greece
b Second Medical Clinic, Aristotle University of Thessaloniki, Ippokration Hospital, Thessaloniki, Macedonia, Greece
c Department of Endocrinology, 424 General Military Hospital, Thessaloniki, Macedonia, Greece
d Department of Clinical Therapeutics, School of Medicine, National and Kapodestrian University of Athens, Athens, Greece
∗ Corresponding author.
E-mail address: spolyzos@auth.gr (S.A. Polyzos). |
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Abstract We read with considerable interest the paper of Shree Harini and Ezhilarasan, summarizing the possible pathophysiological connections between the modulators of canonical Wnt/ β-catenin pathway and nonalcoholic fatty liver disease (NAFLD) [1]. The authors supported with evidence that Wnt/ β-catenin signaling contributes to hepatic homeostasis by regulating hepatic development, regeneration and metabolism. They also supported that dysregulation of modulators of Wnt/ β-catenin signaling is not only implicated in the development of NAFLD, but also in its progression to nonalcoholic steatohepatitis (NASH), hepatic fibrosis and hepatocellular carcinoma (HCC).
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