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| Gut microbiome and nonalcoholic fatty liver disease |
| Meng-Yuan Wu a , b , Jian-Gao Fan b , c , ∗ |
a Xiangya School of Medicine, Central South University, Changsha 410013, China
b Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
c Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China
∗Corresponding author at: Department of Gastroenterology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
E-mail address: fanjiangao@xinhuamed.com.cn (J.-G. Fan). |
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Abstract Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver disease globally and imposed a heavy economic burden on society and individuals. To date, the pathological process of NAFLD is not yet fully elucidated. Compelling evidences have demonstrated the pivotal role of gut microbiota in the pathogenesis of NAFLD, and gut dysbiosis has been commonly observed in patients with NAFLD. Gut dysbiosis impairs gut permeability, allowing the translocation of bacterial products such as lipopolysac- charides (LPS), short-chain fatty acids (SCFAs), and ethanol to the liver via portal blood flow. This review aimed to shed light on the underlying mechanisms by which gut microbiota influences the development and progression of NAFLD. In addition, the potential application of gut microbiome as a non-invasive diagnostic tool and a novel therapeutical target was reviewed.
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2023, Vol. 22 
