|
|
|
| Older liver grafts from donation after circulatory death are associated with impaired survival and higher incidence of biliary non-anastomotic structure |
| Tian Shen a , Shan-Hua Zheng b , Jun Chen c , Zhi-Sheng Zhou d , Meng-Fan Yang c , Xiang-Yan Liu a , Jun-Li Chen d , Shu-Sen Zheng a , b , e , f , Xiao Xu c , e , f , ∗ |
a Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Hangzhou 310022, China
b Division of Hepatobiliary Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
c Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
d China Liver Transplant Registry, Hangzhou 310003, China
e NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China
f Institute of Organ Transplantation, Zhejiang University, Hangzhou 310003, China
∗Corresponding author at: Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
E-mail address: zjxu@zju.edu.cn (X. Xu). |
|
|
|
Abstract Background: Grafts from older donors after circulatory death were associated with inferior outcome in liver transplants in the past. But it has seemed to remain controversial in the last decade, as a result of modified clinical protocols, selected recipients, and advanced technology of organ perfusion and preservation. The present study aimed to examine the impact of older donor age on complications and survival of liver transplant using grafts from donation after circulatory death (DCD).
Methods: A total of 944 patients who received DCD liver transplantation from 2015 to 2020 were included and divided into two groups: using graft from older donor (aged ≥65 years, n = 87) and younger donor (age < 65 years, n = 857). Propensity score matching (PSM) was applied to eliminate selection bias.
Results: A progressively increased proportion of liver transplants with grafts from older donors was observed from 1.68% to 15.44% during the study period. The well-balanced older donor ( n = 79) and younger donor ( n = 79) were 1:1 matched. There were significantly more episodes of biliary non-anastomotic stricture (NAS) in the older donor group than the younger donor group [15/79 (19.0%) vs. 6/79 (7.6%); P = 0.017]. The difference did not reach statistical significance regarding early allograft dysfunction (EAD) and primary non-function (PNF). Older livers had a trend toward inferior 1-, 2-, 3-year graft and overall survival compared with younger livers, but these differences were not statistically sig- nificant (63.1%, 57.6%, 57.6% vs. 76.9%, 70.2%, 67.7%, P = 0.112; 64.4%, 58.6%, 58.6% vs. 76.9%, 72.2%, 72.2%, P = 0.064). The only risk factor for poor survival was ABO incompatible transplant ( P = 0.008) in the older donor group. In the subgroup of ABO incompatible cases, it demonstrated a significant difference in the rate of NAS between the older donor group and the younger donor group [6/8 (75.0%) vs. 3/14 (21.4%); P = 0.014].
Conclusions: Transplants with grafts from older donors (aged ≥65 years) after circulatory death are more frequently associated with inferior outcome compared to those from younger donors. Older grafts from DCD are more likely to develop NAS, especially in ABO incompatible cases.
|
|
|
|
|
|
| [1] |
. Thanks[J]. Hepatobiliary Pancreat Dis Int, 2023, 22(6): 661-A9. |
|
|
|
|
2023, Vol. 22 
