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Chinese expert consensus on quantitatively monitoring and assessing immune cell function status and its clinical application (2024 edition) |
Lin Zhou a , b , Ji-Qiao Zhu a , b , Jian-Tao Kou a , b , Wen-Li Xu a , b , Shao-Cheng Lyu a , b , Guo-Sheng Du b , c , Hong-Wei Yang c , Jian-Feng Wang d , Xiao-Peng Hu e , Chun-Zhao Yu f , Chun-Hui Yuan g , Dong-Dong Han h , Cui-Qin Sang i , Bo Li j , Jie Gao k , Hai-Zhi Qi l , Li-Ming Wang m , Ling Lyu n , Hao Liu o , Jian-Yong Wu p , Ren Lang a , Qiang He a , ∗, Xian-Liang Li a , ∗ |
a Department of Hepatobiliary and Pancreatic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
b Beijing Organ Transplant Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
c Organ Transplantation Center, General Hospital of Northern Theater Command, Shenyang 110010, China
d Department of Interventional Therapy, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
e Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
f Department of General Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China
g Department of General Surgery, Peking University Third Hospital, Beijing 100191, China
h Liver Transplantation Department, China-Japan Friendship Hospital, Beijing 100029, China
i Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
j Department of Hepatobiliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, China
k Department of Hepatobiliary Surgery, Peking University People’s Hospital, Beijing 100871, China
l Department of General Surgery/Organ Transplant Center, The Second Xiangya Hospital of Central South Univercity, Changsha 410011, China
m Organ Transplant Center, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China
n Department of General Surgery, Jiangsu Provincial People’s Hospital, Nanjing 210029, China
o Department of Hepatobiliary Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
p Kidney Transplant Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
∗ Corresponding authors.
E-mail addresses: heqiang349@sina.com (Q. He), lixianliangbjcy@126.com (X.-L. Li). |
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Abstract The immune system is the cornerstone of human health, with most diseases and health conditions closely related to immune status. Therefore, immune status management is a core health issue. In recent years, significant research breakthroughs in immunosuppressants, immune cell therapy, and immune checkpoint inhibitors have enabled clinical experts and researchers to effectively modulate immune status and regulate immunity more efficient. Key questions in the field of immunology include: How can immune function be visually assessed? What constitutes normal immune cell function status? How can immune cell function status be quantitatively evaluated? How can a standardized system for assessing immune cell function status be established? Currently, there is no consensus on these issues worldwide. On August 28, 2023, the National Natural Science Foundation of China announced the National Major Research Plan: Immune Power Digital Decoding Research. Traditional research models have failed to systematically reveal the generation and evolution of immune power. Therefore, China has begun to focus on clarifying the scientific connotation of immune power from multiple perspectives, comprehensively understanding the operating mechanism of the human immune system under health and disease states, deciphering the immune code with a new research paradigm, and promoting the visualization of immunity, which is not only of great significance in clinical disease treatment, but also served in healthy China development strategy.
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