Ferritinophagy: A new idea for liver diseases regulated by ferroptosis
Zi-Bing Qian a , Jun-Feng Li a , b , Wan-Yuan Xiong a , Xiao-Rong Mao a , c , ∗
a The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China
b Institute of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou 730000, China
c Department of Infectious Disease, The First Hospital of Lanzhou University, Lanzhou 730000, China
∗Corresponding author at: Department of Infectious Disease, The First Hospital of Lanzhou University, Lanzhou 730000, China.
E-mail address: mxr2013@126.com (X.-R. Mao).
Abstract：Background: The discovery of regulatory cell death has led to a breakthrough in the therapeutic field. Various forms of cell death, such as necrosis, apoptosis, pyroptosis, autophagy, and ferroptosis, play an important role in the development of liver diseases. In general, more than one form of cell death pathways is responsible for the disease state. Therefore, it is particularly important to study the regulation and interaction of various cell death forms in liver diseases.
Data sources: We performed a PubMed search up to November 2022 with the following keywords: ferritinophagy, ferroptosis, and liver disease. We also used terms such as signal path, inducer, and inhibitor to supplement the query results.
Results: This review summarized the basic characteristics of ferritinophagy and ferroptosis and the regulation of ferroptosis by ferritinophagy and reviewed the key targets and treatment strategies of ferroptosis in different liver diseases.
Conclusions: Ferritinophagy is a potential therapeutic target in ferroptosis-related liver diseases.
. [J]. Hepatobiliary Pancreat Dis Int, 2024, 23(2): 160-170.
Qian ZB, Li JF, Xiong WY, Mao XR. Ferritinophagy: A new idea for liver diseases regulated by ferroptosis. Hepatobiliary Pancreat Dis Int, 2024, 23(2): 160-170.
2024, Vol. 23 
