miR-215 overexpression distinguishes ampullary carcinomas from pancreatic carcinomas
Dong Ho Choi, Sang Jae Park and Hark Kyun Kim
Seoul, Korea
Author Affiliations: Department of Surgery, Hanyang University School of Medicine, 222 Wangsimni-ro, Seongdong, Seoul, 133-791, Korea (Choi DH); Center for Liver Cancer (Park SJ) and Biomolecular Function Research Branch (Kim HK), National Cancer Center, 323 Ilsan-ro, Goyang, Gyeonggi, 410-769, Korea
Corresponding Author: Hark Kyun Kim, MD, PhD, Biomolecular Function Research Branch, Research Institute, National Cancer Center, 323 Ilsan-ro, Goyang, Gyeonggi, 410-769, Republic of Korea (Tel: +82-31-9202238; Fax: +82-31-9202006; Email: hkim@ncc.re.kr)
Distinguishing ampullary carcinoma from pancreatic carcinoma is important because of their different prognoses. microRNAs are differentially expressed according to the tissue of origin. However, there is rare research on the differential diagnosis between the two types of cancers by microRNA in periampullary cancers. The present study was undertaken to compare microRNA profiles between ampullary and pancreatic carcinomas using microarrays. miR-215 was most significantly overexpressed in ampullary carcinomas; whereas the expressions of miR-134 and miR-214 were significantly lower in ampullary carcinomas than in pancreatic carcinomas. When these discriminatory microRNAs were applied to liver metastases, they were correctly predicted for the tissue of origin. Although this study is limited by small sample size, striking difference in microRNA expression and concordant expression of discriminating microRNAs in primary tumors and metastases suggest that these novel discriminatory microRNAs warrant future validation.
2015, Vol. 14 
