Characteristics of recipients with complete immunosuppressant withdrawal after adult liver transplantation
Lei Geng, Jun-Jie Huang, Bing-Yi Lin, Tian-Chi Chen, Tian Shen and Shu-Sen Zheng
Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Geng L, Lin BY, Shen T and Zheng SS); Key Lab of Combined Multi-Organ Transplantation, Ministry of Public Health and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, China (Geng L, Huang JJ, Lin BY, Chen TC, Shen T and Zheng SS)
Corresponding Author: Shu-Sen Zheng
(Email: shusenzheng@zju.edu.cn)
Abstract：To the Editor:
Liver transplantation (LT) is an effective therapeutic method for end-stage liver diseases. Although rejection is commonly mild or moderate in LT compared with other solid organs transplantation, it is still requiring a life-long immunosuppressive therapy. Meanwhile, LT is less sensitive to rejection than other organs transplantation due to liver immune privilege which even allows the success of LT with positive across mismatches of blood group and complete major histocompatibility complex.[1, 2] During the early period of transplantation, clinical operational tolerance (COT) could be achieved on account of the genetic identity between recipient and donor.[3] Over the last decades, there is solid evident supporting that approximately 20% of LT recipients could develop COT, defined as maintaining normal graft function beyond one year completely without administering any immunosuppressive drugs.[4] Completely withdrawal of immunosuppressive agents (ISA) extinguished the ISA related adverse effects and improved the post-transplant survival time.[5]
2017, Vol. 16 
