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| Clinical significance of TGF-β1 and β-glucuronidase synchronous detection in human pancreatic cancer |
| Hui Yue, Bo Yang, Hong Zhang, Shan-De Zhu, Xiao-Ju Du, Xin-Li Feng, Zhong Yu, Yu-Ting Xia and Jie-Ping Yu |
From the Department of Digestive Diseases, People’s Hospital, Wuhan University, Wuhan 430071, China (Yue H and Yu JP); Department of Liver and Biliary Surgery and Digestive Diseases, General Hospital of Shenyang Military Region, Shenyang 110016, China (Yang B, Zhu SD, Du XJ, Feng XL and Xia YT); Department of Pathology, Chinese Medical University, Shenyang 110005, China (Zhang H and Yu Z)
Correspondence: Hui Yue, MD (Tel: 86-24-23056031; Email: kyk567@263.net) |
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Abstract Objective: To investigate the relation of transfer growth factor (TGF-β1) and β-glucuronidase (β-GCD) on the occurrence and progress of pancreatic cancer.
Methods: The expression of TGF-β1 and β-GCD in the pancreatic cancer tissue and normal pancreatic tissue was determined synchronously using ABC method of immunohistochemistry.
Results: The percentage of TGF-β1 positive cells was significantly higher in pancreatic cancer tissue (43.8%±5.2%) than in adjacent pancreatic tissue (28.7%±3.6%, P<0.01). The worse the cancer cells differentiated and lymph nodes metastasis, the more over-expression of TGF-β1. The percentage of β-GCD positive cells was also significantly higher in the pancreatic cancer tissue (62.5%±4.1%) than in the adjacent pancreatic tissue (33.5%±2.8%, P<0.01). The degree of over-expression of β-GCD was related to the degree of cancer cells differentiation, but not to the lymph nodes metastasis. The expression of TGF-β1 was significantly correlated with the expression of β-GCD in pancreatic cancer tissue.
Conclusions: The genesis of pancreatic cancer results from multi-factor, multi-step and multi-gene variation. The synchronous detection of TGF-β1 and β-GCD helps to determine the malignant degree of tumors and the prognosis of patients with such disease.
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2002, Vol. 1 
