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| Pathogenesis of cholangiocarcinoma in the porta hepatis and infection of hepatitis virus |
| Xiao-Fang Liu, Sheng-Quan Zou and Fa-Zu Qiu |
Yantai, China
From the Department of Hepatobiliary Surgery of Affiliated Yantai Yuhuangding Hospital, Qingdao University Medical College, Yantai 264000, China (Liu XF); and Department of General Surgery of Tongji Medical Hospital, Wuhan 430030, China (Zou SQ and Qiu FZ)
Correspondence: Xiao-Fang Liu, MD (Tel: 86-535-6691 999; Fax: 86-535-6665839; Email: liu634@263.net) |
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Abstract OBJECTIVE: To study the correlation between human cholangiocarcinoma in the porta hepatis and the infection of hepatitis virus.
METHODS: Immunohistochemistry was used to detect HBxAg and HCV-C protein in formalin-fixed and paraffin-embedded samples taken from 68 patients with cholangiocarcinoma in the porta hepatis. The findings were reviewed against the clinical records of the patients.
RESULTS: Six patients (8.8%) were positive for HBxAg and 24 (35%) for HCV-C protein, respectively. One patient was positive for both HBxAg and HCV-C protein. There were statistically differences in the extent of differentiation, invasion, lymph-node metastasis, and treatment between the patients with cholangiocarcinomas in the porta hepatis with HB(C)V infection and those without infection.
CONCLUSIONS: HB(C)V infection is correlated to the development of cholangiocarcinoma in the porta hepatis. The tumor with HB(C)V infection may have a higher malignancy biologically and poorer prognosis. HBxAg and HCV-C protein may play an important role in the pathogenesis of cholangiocarcinoma in the porta hepatis.
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2003, Vol. 2 
