|
|
Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-α and ribavirin in patients with chronic hepatitis C |
Jian Jiao and Jiang-Bin Wang |
Changchun, China
Author Affiliations: Digestive Department, China-Japan Union Hospital, Jilin University, Changchun 130031, China (Jiao J and Wang JB)
Corresponding Author: Jian Jiao, MD, Digestive Department, China-Japan Union Hospital, Jilin University, Changchun 130031, China (Tel: 86-431-4646331 ext 5850; Email: zxyjj@sohu.com) |
|
|
Abstract BACKGROUND: Hepatitis C virus (HCV) is a worldwide common disease. Some predictive factors influencing the response to interferon alpha (IFN-α) therapy have been identified, but the conclusions differ in various counties and areas. The aim of this study was to study the associations between HCV genotypes, HLA-DRB alleles and their response to IFN-α and ribavirin in Chinese patients with chronic hepatitis C in Northeast China.
METHODS: HCV genotypes of 113 patients with HCV were investigated. Gene chips were used to analyze the frequency of HLA-DRB in 25 of these patients and their response to IFN-α and ribavirin. The associations of HCV genotypes, HLA-DRB alleles and their response to IFN-α and ribavirin were also studied.
RESULTS: The response rates differed in several types of HCV, with HCV 2b being the highest (57.78%), HCV 1a and 2a lower (46.15% and 47.62%) and HCV 1b the lowest (11.76%). The response rates to IFN-α and ribavirin in patients with DRB1*07 were higher than those with DRB1*04. Sex, HCV type and HLA-DRB were all related to the response. Most female patients with HCV 2b and HLA-DRB1*07 presented complete response, whereas male patients with HCV 1b and HLA-DRB1*04 usually demonstrated no response. DRB1*07 allele and HCV 2b were the factors closely related to the response.
CONCLUSIONS: The response rate of HCV 1b may be the lowest even IFN-α and ribavirin are combined in treatment. Not only virus but also the host plays an important role in anti-virus therapy. Thus, it is necessary to adjust the host’s immune status to accelerate the clearance of HCV.
|
|
|
|
|
Cite this article: |
Jiao J,
Wang JB.
Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-α and ribavirin in patients with chronic hepatitis C.
Hepatobiliary Pancreat Dis Int
2005;
4(1):
80-83. DOI:
|
|
|
|
URL: |
http://dx.doi.org/ OR http://www.hbpdint.com/EN/Y2005/V4/I1/80 |
|
|
|