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| Diagnosis and differentiation of rejection after liver transplantation: report of 5 cases |
| Jia-Wei Chen, Da-Zhi Chen and Zhao-Rui Yang |
Shanghai, China
Author Affiliations: Department of Pathology, First Affiliated Hospital, Shanghai Jiaotong University, Shanghai 200080, China (Chen JW and Yang ZR); Department of Surgery, Beijing Chaoyang Hospital, Beijing 100020, China (Chen DZ)
Corresponding Author: Jia-Wei Chen, MD, PhD, Department of Pathology, First Affiliated Hospital, Shanghai Jiaotong University, Shanghai 200080, China (Tel: 86-21-63240090ext4502; Email: jiaweichen2000@sina.com) |
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Abstract BACKGROUND: The most common complications after liver transplantation are acute and chronic rejection. Although special changes can be found clinically and pathologically in both of them, sometimes other complications such as preservation injury, recurrent disease (HBV) and hepatic artery thrombosis should be differentiated from them.
METHODS: Five patients with various complications after liver transplantation were synthetically analyzed according to their clinical information, laboratory tests and liver biopsy findings so as to find out the clinical rules and the histological features.
RESULTS: Special changes and diagnostic standards were found clinically and pathologically in both acute and chronic rejection. Other complications such as fibrosing cholestatic hepatitis and hepatic artery thrombosis also had their own pathological features. Evaluation of donor liver should be done before liver transplantation.
CONCLUSION: It is very important to understand and master the diagnostic standards of rejection and the major points for its differentiation.
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2005, Vol. 4 
