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| Establishment of a novel pig model of pancreatoduodenal allotransplantation |
| Jian-Shui Li, Yong Tang, Jiang-Tao Wei and Zhao-Da Zhang |
Chengdu, China
Author Affiliations: Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041, China (Li JS, Tang Y and Zhang ZD); and Department of Anesthesia, Chengdu Railway Central Hospital, Chengdu 610081, China (Wei JT)
Corresponding Author: Zhao-Da Zhang, MD, Department of General Surgery,West China Hospital,Sichuan University,Chengdu 610041, China (Tel: 86-28-85502321; Fax: 86-28-85502321; Email: zdzhang@wcums.edu.cn) |
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Abstract BACKGROUND: Pancreas transplantation is a valid therapy for patients with type 1 diabetes mellitus (IDDM). This study was undertaken to establish a stable pig model of whole pancreatoduodenal allotransplantation of physiologically coincidence for pancreas transplantation.
METHODS: The IDDM pig model was made by resection of the pancreas from the recipient. The portal vein of the donor was end-to-side anastomosed to the anterior mesenteric vein (equal to the superior mesenteric vein) or the portal vein of the recipient. The far end of the celiac axis was anastomosed to each other. With end-to-side fashion, the duodenum of the donor was anastomosed to the jejunum of the recipient.
RESULTS: In 16 transplantations, results were satisfactory. The anatomical results and immune function including the function of the pancreas were similar to those of human being.
CONCLUSION: Of the pancreas of the pig, this study of pancreatic transplantation shows that the novel pig whole pancreatoduodenal allotransplantation model is ideal.
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2005, Vol. 4 
