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Intramuscular hepatitis B immune globulin combined with lamivudine in prevention of hepatitis B recurrence after liver transplantation |
Mao-Lin Yan, Lu-Nan Yan, Bo Li, Yong Zeng, Tian-Fu Wen, Wen-Tao Wang, Jia-Yin Yang, Ming-Qing Xu, Zhi-Hui Li and Yong-Bing Chen |
Chengdu, China
Author Affiliations: Liver Transplantation Group of Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, China (Yan ML, Yan LN, Li B, Zeng Y, Wen TF, Wang WT, Yang JY, Xu MQ, Li ZH and Chen YB)
Corresponding Author: Lu-Nan Yan, MD, Liver Transplantation Group of Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, China (Tel: 86-28-85422476; Fax: 86-28-85422072; Email: yanlvnan@hotmail.com) |
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Abstract BACKGROUND: Combined hepatitis B immune globulin (HBIg) and lamivudine in prophylaxis of the recurrence of hepatitis B after liver transplantation has significantly improved the survival of HBsAg positive patients. This study was undertaken to evaluate the outcomes of liver transplantation for patients with hepatitis B virus (HBV).
METHODS: A retrospective chart analysis and a review of the organ transplant database identified 51 patients (43 men and 8 women) transplanted for benign HBV-related cirrhotic diseases between June 2002 and December 2004 who had survived more than 3 months. HBIg was administered intravenously during the first week and intramuscularly thereafter.
RESULTS: At a median follow-up of 14.1 months, the overall recurrence rate in the 51 patients was 3.9% (2/51). The overall patient survival was 88.3%, and 82.4% after 1 and 2 years, respectively. A daily oral dose of 100 mg lamivudine for 2 weeks before transplantation for 10 patients enabled 57.1% (4/7) and 62.5% (5/8) of HBV-DNA and HBeAg positive patients respectively to convert to be negative. Intramuscular HBIg was well tolerated in all patients.
CONCLUSION: Lamivudine combined with intramuscular HBIg can effectively prevent allograft from the recurrence of HBV after liver transplantation.
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Cite this article: |
Yan ML,
Yan LN,
Li B,
et al.
Intramuscular hepatitis B immune globulin combined with lamivudine in prevention of hepatitis B recurrence after liver transplantation.
Hepatobiliary Pancreat Dis Int
2006;
5(3):
360-363. DOI:
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URL: |
http://dx.doi.org/ OR http://www.hbpdint.com/EN/Y2006/V5/I3/360 |
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