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| Large cell neuroendocrine carcinoma of the ampulla of Vater |
| Eswaran Selvakumar, Velayutham Vimalraj, Shanmugasundaram Rajendran, Tirupporur G. Balachandar, Devy G. Kannan, Satyanesan Jeswanth, Palaniappan Ravichandran, Arunachalam Sundaram and Rajagopal Surendran |
Tamilnadu, India
Author Affiliations: Departments of Pathology and Surgical Gastroenterology, Center for G.I.Bleeding & Division of Hepatobiliary Pancreatic Diseases, Government Stanley Medical College Hospital, the Tamilnadu Dr. M.G.R. Medical University, Chennai, Tamilnadu, India (Selvakumar E, Vimalraj V, Rajendran S, Balachandar TG, Kannan DG, Jeswanth S, Ravichandran P, Sundaram A and Surendran R)
Corresponding Author: Rajagopal Surendran, MCh, Department of Surgical Gastroenterology, Government Stanley Medical College Hospital, Chennai-600001, Tamilnadu, India (Tel: 0091-44-25281354; Fax: 0091-44-25288384; Email: Stanleygastro@yahoo.com) |
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Abstract BACKGROUND: Neuroendocrine tumors of the ampulla of Vater are extremely rare, and few cases of large cell neuroendocrine carcinoma (LCNEC) of the ampulla have been reported.
METHODS: A 48-year-old male with obstructive jaundice was admitted to our hospital. On examination the patient was found to have a periampullary growth and subsequently underwent the Whipple's procedure.
RESULTS: Histopathological examination and immunohistochemistry revealed features of LCNEC of the ampulla of Vater. The patient developed multiple liver metastases 6 months after Whipple's procedure.
CONCLUSION: LCNEC of the ampulla of Vater is rare and highly aggressive, with a dismal prognosis.
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2006, Vol. 5 
