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| 103Pd radioactive stent inhibits biliary duct restenosis and reduces smooth muscle actin expression during duct healing in dogs |
| Gui-Jin He, Qin-Yi Gao, Shu-He Xu, Hong Gao, Tao Jiang, Xian-Wei Dai and Kai Ma |
Shenyang, China
Author Affiliations: Department of General Surgery, Second Affiliated Hospital, China Medical University, Shenyang 110004, China (He GJ, Gao QY, Xu SH, Gao H, Jiang T, Dai XW and Ma K)
Corresponding Author: Gui-Jin He, MD, Department of General Surgery, Second Affiliated Hospital, China Medical University, Shenyang 110004, China (Tel: 86-24-83955082; Email: 23318199@163.com) |
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Abstract BACKGROUND: This study was designed to assess the expression of smooth muscle actin (SMA) in the healing process after implanting a 103Pd radioactive stent in the biliary duct, and to discuss the function and significance of this stent in preventing biliary stricture formation.
METHODS: A model of biliary injury in dogs was made and then a 103Pd radioactive stent was positioned in the biliary duct. The expression and distribution of SMA were assessed in the anastomotic tissue 30 days after implantation of the stent.
RESULTS: SMA expression was less in the 103Pd stent group than in the ordinary stent group. The 103Pd stent inhibited scar contracture and anastomotic stenosis.
CONCLUSION: The 103Pd stent can reduce the expression of SMA in the healing process and inhibit scar contracture and anastomotic stenosis in the dog biliary duct.
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| Cite this article: |
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He GJ,
Gao QY,
Xu SH,
et al.
103Pd radioactive stent inhibits biliary duct restenosis and reduces smooth muscle actin expression during duct healing in dogs.
Hepatobiliary Pancreat Dis Int
2006;
5(4):
595-598. DOI:
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| URL: |
| http://dx.doi.org/ OR http://www.hbpdint.com/EN/Y2006/V5/I4/595 |
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2006, Vol. 5 
