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| Regulating regulatory T cells to achieve transplant tolerance |
| Ran Tao and Wayne W. Hancock |
Pittsburgh, USA
Author Affiliations: Division of Transplantation Immunology, Department of Pathology and Laboratory Medicine, Joseph Stokes, Jr., Research Institute and Biesecker Pediatric Liver Center, Children’s Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA 19104, USA (Tao R and Hancock WW); Division of Transplant Surgery, Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA (Tao R)
Corresponding Author: Ran Tao, MD, Division of Transplant Surgery, Thomas E. Starzl Transplantation Institute, UPMC Montefiore, 7 South, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA (Tel: 412-334-6212; Email: taor@upmc.edu) |
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Abstract BACKGROUND: Regulatory T cells (Tregs) play crucial roles in both induction and maintenance of tolerance. This active immune regulation may contribute not only to the control of immune responses to self-antigens and thereby prevent autoimmune diseases, but also the control of responses to non-self molecules in adaptive immunity. Numerous experimental and clinical studies indicate that manipulating the balance between regulatory and responder T cells is an effective strategy to control immune responsiveness after transplantation.
DATA SOURCES: Literature search was conducted using PubMed on the related subjects. Part of the material was based on the most recent work in the authors' laboratory.
RESULTS: We propose some new strategies to achieve transplant tolerance in rodent animals via manipulating Treg function, including using histone deacetylase (HDAC) inhibitor to regulate Foxp3 transcription and enhance Treg suppression, induction of Treg-sparing apoptosis via Nur77, and identification of the co-inhibitory molecule herpes virus entry mediator (HVEM) as an effector molecule for Treg function.
CONCLUSION: Regulation of Treg function will definitely provide us very promising tools to achieve clinical tolerance in the future.
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2007, Vol. 6 
