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Clinical features of solitary necrotic nodule of the liver |
Yan-Ming Zhou, Bin Li, Feng Xu, Bin Wang, Dian-Qi Li, Peng Liu and Jia-Mei Yang |
Shanghai, China
Author Affiliations: Department of Hepato-Biliary-Pancreato-Vascular Surgery, First Xiamen Hospital, Fujian Medical University, Xiamen 361003, China (Zhou YM and Li B); Department of Special Treatment (Xu F, Li DQ, Liu P and Yang JM), and Department of Pathology (Wang B), Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
Corresponding Author: Jia-Mei Yang, MD, Department of Special Treatment, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China (Tel: 86-21-25070808; Fax: 86-21-65562400; Email: yjm.1952@yahoo.com.cn) |
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Abstract BACKGROUND: Solitary necrotic nodule of the liver is a rare nonmalignant lesion. The present study aimed to clarify the clinical features of the disease.
METHOD: The medical records of 51 patients with histologically confirmed solitary necrotic nodule of the liver who received surgical resection at our institution were retrospectively reviewed.
RESULTS: Solitary necrotic nodule of the liver was found mainly in males (68.6%, 35/51), and patients ranged in age from 5 to 69 years with a mean of 45.3. Most of the patients (72.5%) had no significant symptoms, with negative results for the serum tumor markers alpha-fetoprotein, carbohydrate antigen 19-9 and carcinoembryonic antigen. The mean diameter of the nodule was 23 mm (range 10-55 mm). Compared with ultrasonographic and computed tomography findings, the specific features of magnetic resonance imaging were more helpful for differential diagnosis of the disease.
CONCLUSIONS: Solitary necrotic nodule of the liver is a rare nonmalignant lesion, showing no notable symptoms and potential complications. The pathological change of the disease is not significant over a lifetime. Conservative treatment and clinical follow-up are recommended.
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