|
|
|
| Posttransplantation lymphoproliferative disorder involving the central nervous system in liver transplant recipients |
| Qing-Sheng Xu, Song Ye, Yong-Qing Zhou, Jian-Feng Sheng, Ke Ye and Shu-Sen Zheng |
Hangzhou, China
Author Affiliations: Department of Neurosurgery (Xu QS, Zhou YQ, Sheng JF and Ye K), and Department of Hepatobiliary and Pancreatic Surgery (Ye S and Zheng SS), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Corresponding Author: Shu-Sen Zheng, MD, PhD, FACS, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Tel: 86-571-87236601; Email: shusenzheng@zju.edu.cn)
Qing-Sheng Xu and Song Ye contributed equally to the article. |
|
|
|
|
Abstract BACKGROUND: Posttransplantation lymphoproliferative disorder (PTLD) involving the central nervous system (CNS) is a rare and serious complication associated with solid organ transplantation. We treated a case of PTLD with CNS involvement in a liver transplant recipient and reviewed the literature.
METHOD: The clinicopathological features of a 53-year-old man were retrospectively analyzed.
RESULTS: Metastasis of the hepatoma was preoperatively considered on the basis of clinical findings. Craniotomy was performed and PTLD was diagnosed pathologically. The patient was treated with antiviral agents, radiation therapy, and chemotherapy; the immunosuppressive medication was reduced. The patient is still alive after follow-up for 14 months.
CONCLUSIONS: Definitive diagnosis of PTLD is only established on the basis of histopathologic evaluation of the tissue. Although there are several ways to manage PTLD with CNS involvement, the prognosis is still poor.
|
|
|
|
|
|
|
|
|
2008, Vol. 7 
