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| Acinar cell carcinoma of the pancreas in a young patient with chronic pancreatitis |
| Fatima-Zahra Kebir, Ahlem Lahmar, Nafaa Arfa, Saber Manai, Mohamed Ali El Ouaer, Saadia Bouraoui, Carole Gouttalier and Sabah Mezabi-Regaya |
Sidi Daoued La Marsa, Tunisia
Author Affiliations: Department of Pathology (Kebir FZ, Lahmar A, Bouraoui S, Gouttalier C and Mezabi-Regaya S) and Department of Surgery (Arfa N, Manai S and Ouaer MAE), Mongi Slim Hospital, 2046 Sidi Daoued La Marsa, Tunisia
Corresponding Author: Nafaa Arfa, MD, Department of Surgery, Mongi Slim Hospital, 2046 Sidi Daoued La Marsa, Tunisia (Email: nafaa.arfa@rns.tn) |
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Abstract BACKGROUND: Acinar cell carcinoma (ACC) is a rare malignancy of the pancreas arising from acinar cells. Unlike ductal adenocarcinoma, this tumor rarely presents with pancreatitis.
METHODS: We present a case of ACC associated with chronic calcifying pancreatitis, and a review of the literature focusing on diagnosis and management.
RESULTS: A 43-year-old man was proposed for Wirsungojejunal derivation for chronic pancreatitis. Histopathological examination of the tissue extracted revealed an ACC. Duodenopancreatectomy was performed. Six months post-operatively, the patient developed hepatic metastasis and was treated with gemcitabine as palliative chemotherapy.
CONCLUSIONS: The clinical presentation of ACC of the pancreas is not specific and the tumor can be under-diagnosed when associated with chronic pancreatitis. Data regarding course, treatment, and prognosis of this tumor are generally lacking.
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2010, Vol. 9 
