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| Impact of human leukocyte antigen matching on hepatitis B virus recurrence after liver transplantation |
| Hong Zhao, Jian-Hua Hu, Lin Zhou, Xiao Xu, Jian Wu, Xue-Qin Meng, Jun Fan and Wei-Hang Ma |
Hangzhou, China
Author Affiliations: State Key Laboratory for Diagnosis and Treatment of Infectious Diseases (Zhao H, Hu JH, Fan J and Ma WH) and Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health (Zhou L, Xu X, Wu J and Meng XQ), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Corresponding Author: Wei-Hang Ma, MD, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Tel: 86-571-87236489; Email: maweihang@zju.edu.cn) |
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Abstract BACKGROUND: Liver transplantation (LT) is an effective therapy for end-stage hepatitis B virus (HBV) infection. Recurrence of HBV is one of the frequent complications. In the present study, we investigated whether human leukocyte antigen (HLA) matching influences the incidence of HBV recurrence, and the time point of HBV recurrence after LT.
METHODS: One hundred and two recipients of LT with end-stage chronic HBV infection were reviewed. The triple-drug immunosuppression regimen consisted of tacrolimus, mycophenolate, and prednisone. All patients were subjected to prophylaxis with hepatitis B immunoglobulin and lamivudine. HLA typing was performed using a sequence-specific primer-polymerase chain reaction kit. Serology for hepatitis B and HBV DNA was examined using a commercial kit.
RESULTS: The incidence of recurrent HBV infection post-LT was 6.86%. The recurrent infection of HBV was independent of the degree of HLA matching (P>0.05). The time point of HBV recurrence, however, was prolonged in HLA-A matched patients compared with matchless patients (P=0.049). The recurrence of HBV infection was independent of HLA compatibility.
CONCLUSIONS: This retrospective analysis showed that more HLA-A locus compatibility is associated with a prolonged time of recurrence of HBV in patients after LT for end-stage HBV infection. The incidence of HBV recurrence is independent of HLA compatibility.
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2010, Vol. 9 
