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Relationship between model for end-stage liver disease score and left ventricular function in patients with end-stage liver disease |
Fu-Rong Sun, Ying Wang, Bing-Yuan Wang, Jing Tong, Dai Zhang and Bing Chang |
Shenyang, China
Author Affiliations: Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, China (Sun FR, Wang Y, Wang BY, Tong J, Zhang D and Chang B)
Corresponding Author: Bing-Yuan Wang, Professor, Department of Gastroenterology, First Affiliated Hospital, China Medical University, Shenyang 110001, China (Tel: 86-24-83282900; Fax: 86-24-83282997; Email: wangby@medmail.com.cn) |
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Abstract BACKGROUND: Decreased cardiac contractility has been observed in cirrhosis, suggesting a latent cardiomyopathy in these patients. This study was designed to evaluate left ventricular structure and function in patients with end-stage liver disease by the model for end-stage liver disease (MELD) scoring system.
METHODS: We recruited 82 patients (72 male, 10 female; mean age 50.3±8.9 years) with end-stage liver disease who underwent orthotopic liver transplantation between January 2002 and May 2008. Seventy-eight patients had cirrhosis and 4 had primary liver cancer. Patients were categorized into three groups on the basis of MELD score: ≤9 (27 patients, 33%); 10-19 (40, 49%); and ≥20 (15, 18%). The relationship between MELD score and cardiac structure and function was determined. Preoperative assessments of blood biochemistry, blood coagulation, serum virology, echocardiography and electrocardiography were performed.
RESULTS: MELD score was positively correlated with enlarged left atrial diameter, increased interventricular septum thickness (IVST), increased aortic flow, corrected QT interval (QTc) extension and cardiac output (P=0.033, 0.002, 0.000, 0.000 and 0.009, respectively). International normalized ratio also had a correlation with the above parameters and enlarged left ventricular end-diastolic diameter (P=0.043, 0.010, 0.000, 0.001, 0.016 and 0.008, respectively). Serum creatinine was positively correlated with IVST (r=0.257, P=0.020), but negatively correlated with early maximal ventricular filling velocity/late diastolic or atrial velocity ratio (r=-0.300, P=0.006). A difference of QTc >440 ms among the three groups was statistically significant (χ2=9.791, P=0.007).
CONCLUSIONS: Abnormalities in cardiac structure and function are common in patients with end-stage liver disease. MELD score is a practically useful approach for the assessment of cardiac function in such patients.
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Cite this article: |
Sun FR,
Wang Y,
Wang BY,
et al.
Relationship between model for end-stage liver disease score and left ventricular function in patients with end-stage liver disease.
Hepatobiliary Pancreat Dis Int
2011;
10(1):
50-54. DOI:
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URL: |
http://dx.doi.org/ OR http://www.hbpdint.com/EN/Y2011/V10/I1/50 |
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