A cooperation agreement was signed by University of California at Los Angeles and the First Affiliated Hospital, Zhejiang University School of Medicine on June 2, 2011, indicating the establishment of a joint liver center at Hangzhou, China. In recent years, a series of scientific cooperation and exchanges have been carried out between the UCLA Medical Center and the First Affiliated Hospital. This endeavor opens a new page for further cooperation between both centers. The sustained efforts of Chinese and American scientists will benefit the patients with liver diseases in the two countries as well as in the other countries.